The top two teams in the NL West collide when the Los Angeles Dodgers host the San Diego Padres on Friday in Los Angeles.

The Dodgers (47-28) have the best record in the National League and lead the division by 2.5 games over the Padres (46-32).

On Thursday, Los Angeles won the first game of the four-game series, 3-1. Los Angeles is a -165 favorite in the latest Dodgers vs. Padres odds from Caesars Sportsbook while San Diego is a +140 underdog.

First pitch is set for 10:10 p.m. ET from Dodger Stadium. The game is one of 15 on the MLB schedule for Friday. 

Elsewhere in the majors, Gerrit Cole takes the mound for the Yankees at Cleveland, and the Cardinals and Phillies start a three-game series in Philadelphia.

Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. 

It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season.

Now, the model has locked in four confident MLB best bets for Friday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in. 

If you successfully parlay the picks, you'd be looking at a payout of almost 13-1. You can see the model's MLB picks for Friday only at SportsLine.  

After simulating every game on Friday 10,000 times, the model is high on the Giants (-155) to beat the White Sox at 10:15 p.m. ET.