2022 MLB odds

The top two teams in the NL West collide when the Los Angeles Dodgers host the San Diego Padres on Friday in Los Angeles.

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The Dodgers (47-28) have the best record in the National League and lead the division by 2.5 games over the Padres (46-32).

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On Thursday, Los Angeles won the first game of the four-game series, 3-1. Los Angeles is a -165 favorite in the latest Dodgers vs. Padres odds from Caesars Sportsbook while San Diego is a +140 underdog.

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First pitch is set for 10:10 p.m. ET from Dodger Stadium. The game is one of 15 on the MLB schedule for Friday.

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Elsewhere in the majors, Gerrit Cole takes the mound for the Yankees at Cleveland, and the Cardinals and Phillies start a three-game series in Philadelphia.

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Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

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The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season.

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It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season.

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Now, the model has locked in four confident MLB best bets for Friday. They all involve games at 7:10 p.m. ET or later, so there's still time to get these MLB picks in.

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If you successfully parlay the picks, you'd be looking at a payout of almost 13-1. You can see the model's MLB picks for Friday only at SportsLine.

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After simulating every game on Friday 10,000 times, the model is high on the Giants (-155) to beat the White Sox at 10:15 p.m. ET.

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